Background: Oxidative stress contributes to both intraocular pressure regulation and glaucomatous neuropathy.\nThe systemic redox status (solitary determination) was examined in primary open-angle glaucoma (POAG) patients\nwith cataract and nonglaucomatous cataract patients. Cataract-matched group comparisons appear more precise in\nthe context of oxidative stress evaluation. The aim of this study was to establish if systemic oxidative status in\nPOAG patients was elevated compared with the cataract only subjects.\nMethods: The study included patients with primary open angle glaucoma (POAG group, n = 30) and controls (non\nPOAG group, n = 25). Serum concentration of lipofuscine (LPS), malondialdehyde (MDA) and activity of total\nsuperoxide dismutase (SOD), and its mitochondrial (Mn-SOD) and cystolic (Cu,Zn-SOD) isoform were measured.\nTotal oxidant state (TOS) and total antioxidant capacity (TAC) in blood were also evaluated.\nResults: Significant increase of LPS (p = 0.0002) and MDA (p = 0.005) concentration was observed in glaucomatous\npatients as compared with controls. Total SOD activity was significantly lowered in the glaucoma group (p = 0.003);\nserum level of Mn-SOD was significantly lower in glaucoma patients (p = 0.048) however, Cu,Zn-SOD was not.\nGlaucoma patients presented elevated mean TOS (p = 0.016). Both groups presented with comparable TAC.\nConclusion: Systemic redox balance of cataract patients was significantly altered in the course of glaucoma.
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